Childhood cancer in the offspring of male sawmill workers occupationally exposed to chlorophenate fungicides

被引:30
作者
Heacock, H
Hertzman, C
Demers, PA
Gallagher, R
Hogg, RS
Teschke, K
Hershler, R
Bajdik, CD
Dimich-Ward, H
Marion, SA
Ostry, A
Kelly, S
机构
[1] Univ British Columbia, Dept Hlth Care & Epidemiol, Vancouver, BC V6T 1Z3, Canada
[2] Univ British Columbia, Sch Occupat & Environm Hyg, Vancouver, BC V6T 1Z3, Canada
[3] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada
[4] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1M9, Canada
关键词
cancer; children; chlorophenols; occupational exposure; paternal exposure; pesticides; reproductive toxicology;
D O I
10.2307/3454610
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The objective of this study was to determine whether paternal occupational exposure to chlorophenol fungicides and their dioxin contaminants is associated with childhood cancer in the offspring of sawmill workers. We used data from 23,829 British Columbian sawmill workers employed for at least 1 continuous year between 1950 and 1985 in 11 sawmills that used chlorophenates. Probabilistic linkage of the sawmill worker cohort to the provincial marriage and birth files produced an offspring cohort of 19,674 children born at least 1 year after the initiation of employment in the period 1952-1988. We then linked the offspring cohort to the British Columbia Cancer Registry. We included all malignancies in cases younger than 20 years of age that appeared on the cancer registry between 1969 and 1993. We calculated standardized incidence ratios (SIRs) using the British Columbia population as a reference. A nested case-control analysis assessed the effects of paternal cumulative exposure and windows of exposure on the risk of developing cancer in the offspring. We identified 40 cases of cancer during 259,919 person-years of follow-up. The all-cancer SIR was 1.0 [95% confidence interval (CI), 0.7-1.4]; the SIR for leukemia was 1.0 (CI, 0.5-1.8); and the SIR for brain cancer was 1.3 (CI, 0.6-2.5). The nested case-control analysis showed slightly increased risks in the highest categories of chlorophenol exposure, although none was staristically significant. Our analyses provide little evidence to support a relationship between the risk of childhood cancer and paternal occupational exposure to chlorophenate Fungicides in British Columbian sawmills.
引用
收藏
页码:499 / 503
页数:5
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