Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

被引：272

作者：

Dreier, Jens P. ^{[1
,2
,3
]}

Fabricius, Martin ^{[4
]}

Ayata, Cenk ^{[5
,6
,7
,8
]}

Sakowitz, Oliver W. ^{[9
,10
]}

Shuttleworth, C. William ^{[11
]}

Dohmen, Christian ^{[12
,13
]}

Graf, Rudolf ^{[13
]}

Vajkoczy, Peter ^{[1
,14
]}

Helbok, Raimund ^{[15
]}

Suzuki, Michiyasu ^{[16
]}

Schiefecker, Alois J. ^{[15
]}

Major, Sebastian ^{[1
,2
,3
]}

Winkler, Maren K. L. ^{[1
]}

Kang, Eun-Jeung ^{[1
,3
]}

Milakara, Denny ^{[1
]}

Oliveira-Ferreira, Ana I. ^{[1
,3
]}

Reiffurth, Clemens ^{[1
,3
]}

Revankar, Gajanan S. ^{[1
]}

Sugimoto, Kazutaka ^{[16
]}

Dengler, Nora F. ^{[1
,14
]}

Hecht, Nils ^{[1
,14
]}

Foreman, Brandon ^{[17
]}

Feyen, Bart ^{[18
,19
]}

Kondziella, Daniel ^{[20
]}

Friberg, Christian K. ^{[4
]}

Piilgaard, Henning ^{[4
]}

Rosenthal, Eric S. ^{[8
]}

Westover, M. Brandon ^{[10
]}

Maslarova, Anna ^{[21
,22
]}

Santos, Edgar ^{[10
]}

Hertle, Daniel ^{[10
]}

Sanchez-Porras, Renan ^{[10
]}

Jewell, Sharon L. ^{[23
]}

Balanca, Baptiste ^{[24
,25
]}

Platz, Johannes ^{[26
]}

Hinzman, Jason M. ^{[27
]}

Lueckl, Janos ^{[1
]}

Schoknecht, Karl ^{[1
,3
,28
]}

Schoell, Michael ^{[10
,29
]}

Drenckhahn, Christoph ^{[1
,30
]}

Feuerstein, Delphine ^{[13
]}

Eriksen, Nina ^{[31
,32
]}

Horst, Viktor ^{[1
,33
]}

Bretz, Julia S. ^{[1
,33
]}

Jahnke, Paul ^{[33
]}

Scheel, Michael ^{[33
]}

Bohner, Georg ^{[33
]}

Rostrup, Egill ^{[31
]}

Pakkenberg, Bente ^{[32
,34
]}

Heinemann, Uwe ^{[1
,28
]}

机构：

[1] Charite Univ Med Berlin, Ctr Stroke Res Berlin, Charite Campus Mitte,Charitepl 1, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[3] Charite Univ Med Berlin, Dept Expt Neurol, Berlin, Germany

[4] Rigshosp, Dept Clin Neurophysiol, Copenhagen, Denmark

[5] Harvard Med Sch, Dept Radiol, Neurovasc Res Lab, Boston, MA USA

[6] Harvard Med Sch, Stroke Serv, Boston, MA USA

[7] Harvard Med Sch, Neurosci Intens Care Unit, Massachusetts Gen Hosp, Boston, MA USA

[8] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[9] Klinikum Ludwigsburg, Dept Neurosurg, Ludwigsburg, Germany

[10] Univ Hosp, Dept Neurosurg, Heidelberg, Germany

[11] Univ New Mexico, Sch Med, Dept Neurosci, Albuquerque, NM 87131 USA

[12] Univ Cologne, Dept Neurol, Cologne, Germany

[13] Max Planck Inst Metab Res, Multimodal Imaging Brain Metab, Cologne, Germany

[14] Charite Univ Med Berlin, Dept Neurosurg, Berlin, Germany

[15] Med Univ Innsbruck, Dept Neurol, Neurocrit Care Unit, Innsbruck, Austria

[16] Yamaguchi Univ, Dept Neurosurg, Grad Sch Med, Ube, Yamaguchi, Japan

[17] Univ Cincinnati, Coll Med, Dept Neurol & Rehabil Med, Neurocrit Care Div, Cincinnati, OH USA

[18] Antwerp Univ Hosp, Dept Neurosurg, Edegem, Belgium

[19] Univ Antwerp, Edegem, Belgium

[20] Rigshosp, Dept Neurol, Copenhagen, Denmark

[21] Univ Hosp, Dept Neurosurg, Bonn, Germany

[22] Univ Bonn, Bonn, Germany

[23] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England

[24] Lyon Neurosci Res Ctr, INSERM, U10128, CNRS,UMR5292,Team TIGER, Lyon, France

[25] Univ Claude Bernard, Lyon, France

[26] Goethe Univ, Dept Neurosurg, Frankfurt, Germany

[27] Univ Cincinnati, Coll Med, Dept Neurosurg, Cincinnati, OH 45267 USA

[28] Charite Univ Med Berlin, Neurosci Res Ctr, Berlin, Germany

[29] Heidelberg Univ, Inst Med Biometry & Informat, Heidelberg, Germany

[30] Segeberger Kliniken, Neurol Ctr, Bad Segeberg, Germany

[31] Rigshosp, Dept Clin Physiol & Nucl Med, Copenhagen, Denmark

[32] Rigshosp, Bispebjerg Frederiksberg Hosp, Res Lab Stereol & Neurosci, Copenhagen, Denmark

[33] Charite Univ Med Berlin, Dept Neuroradiol, Berlin, Germany

[34] Univ Copenhagen, Panum Inst, Fac Hlth & Med Sci, Copenhagen, Denmark

[35] Columbia Univ Coll Phys & Surg, Neurocrit Care, 630 W 168th St, New York, NY 10032 USA

[36] Univ New Mexico, Sch Med, Dept Neurosurg, Albuquerque, NM 87131 USA

[37] Zlotowski Ctr Neurosci, Dept Physiol & Cell Biol, Beer Sheva, Israel

[38] Soroka Univ, Med Ctr, Dept Neuroradiol, Beer Sheva, Israel

[39] Soroka Univ, Med Ctr, Dept Neuroradiol, Beer Sheva, Israel

[40] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, Beer Sheva, Israel

[41] Dalhousie Univ, Fac Med, Dept Med Neurosci, Halifax, NS, Canada

[42] Univ Cologne, Dept Neurosurg, Cologne, Germany

[43] Med Coll Georgia, Dept Neurosurg, Augusta, GA 30912 USA

[44] Med Coll Georgia, Brain & Behav Discovery Inst, Augusta, GA 30912 USA

[45] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada

[46] Univ Szeged, Fac Med, Dept Med Phys & Informat, Szeged, Hungary

[47] Univ Szeged, Fac Sci & Informat, Szeged, Hungary

[48] Univ Utah, Dept Neurol, Salt Lake City, UT USA

[49] AniRA Neurochem Technol Platform, Lyon, France

[50] Univ Autonoma Barcelona, Vall dHebron Univ Hosp, Dept Neurosurg, Neurotraumatol & Neurosurg Res Unit UNINN, Barcelona, Spain

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2017年 / 37卷 / 05期

基金：

美国国家卫生研究院; 英国惠康基金; 匈牙利科学研究基金会;

关键词：

Spreading depolarization; spreading depression; anoxic depolarization; asphyxial depolarization; peri-infarct depolarization; spreading ischemia; brain trauma; focal ischemia; subarachnoid hemorrhage; intracerebral hemorrhage; epileptogenesis; epilepsy; cerebral blood flow; brain edema; vasospasm; global ischemia; neurovascular coupling; neuroprotection; neurocritical care; TRAUMATIC BRAIN-INJURY; ANEURYSMAL SUBARACHNOID HEMORRHAGE; ISCHEMIC NEUROLOGICAL DEFICITS; LOW EXTRACELLULAR MAGNESIUM; FOCAL CEREBRAL-ISCHEMIA; RAT HIPPOCAMPAL CA1; ANOXIC DEPOLARIZATION; PERIINFARCT DEPOLARIZATIONS; IN-VIVO; MIGRAINE AURA;

D O I：

10.1177/0271678X16654496

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neuro-critical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.

引用

页码：1595 / 1625

页数：31

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