Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro

被引：27

作者：

Chatterton, RT

Lydon, JP

Mehta, RG

Mateo, ET

Pletz, A

Jordan, VC

机构：

[1] Northwestern Univ, Sch Med, Dept Obstet Gynecol, Chicago, IL 60611 USA

[2] Northwestern Univ, Sch Med, Dept Physiol, Chicago, IL 60611 USA

[3] Northwestern Univ, Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA

[4] Northwestern Univ, Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL USA

[5] Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

[6] Univ Illinois, Div Surg Oncol, Coll Med, Chicago, IL USA

来源：

CANCER LETTERS | 2002年 / 188卷 / 1-2期

关键词：

carcinogen; progesterone receptor; mammary; tumor; gene knockout;

D O I：

10.1016/S0304-3835(02)00461-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Glands of wild-type (WT) and progesterone receptor knockout (PRKO) mice were exposed to 7,12-dimethylbenz[a]anthracene (DMBA) while cultured in serum-free medium containing insulin, prolactin, aldosterone, and cortisol. Glands of WT but not PRKO mice responded to DMBA with epithelial hyperplasia after 10 days in this medium. After culture without prolactin and adrenocortical hormones for an additional 14 days, hyperplastic lesions were present only in glands of WT mice. We conclude that in the absence of PR, epithelial structures are resistant to the carcinogenic action of DMBA. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：47 / 52

页数：6

共 31 条

[1]

TOO MANY RODENT CARCINOGENS - MITOGENESIS INCREASES MUTAGENESIS [J].