DNA microarrays in herbal drug research

被引：51

作者：

Chavan, Preeti ^{[1
]}

Joshi, Kalpana ^{[1
]}

Patwardhan, Bhushan ^{[1
]}

机构：

[1] Univ Poona, Interdisciplinary Sch Hlth Sci, Bioprospecting Lab, Pune 411007, Maharashtra, India

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2006年 / 3卷 / 04期

关键词：

drug discovery; evidence-based medicine; gene expression; genotyping; pharmacodynamics; transcription profiling;

D O I：

10.1093/ecam/nel075

中图分类号：

R [医药、卫生];

学科分类号：

10 [医学];

摘要：

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.

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收藏

页码：447 / 457

页数：11

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