New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

被引：467

作者：

Greenberg, Michael E. ^{[2
]}

Xu, Baoji ^{[3
]}

Lu, Bai ^{[4
]}

Hempstead, Barbara L. ^{[1
]}

机构：

[1] Weill Cornell Med Coll, New York, NY 10065 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Georgetown Univ, Washington, DC 20057 USA

[4] Natl Inst Child Hlth & Dev, NIH, Bethesda, MD 20847 USA

来源：

JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 41期

基金：

美国国家卫生研究院;

关键词：

ACTIVITY-DEPENDENT SECRETION; NEUROTROPHIC FACTOR; NEURONAL-ACTIVITY; HIPPOCAMPAL-NEURONS; PROTEIN-SYNTHESIS; PROBDNF; BRAIN; PLASTICITY; EXPRESSION; TRANSCRIPTION;

D O I：

10.1523/JNEUROSCI.3566-09.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and protein, and secretion and extracellular conversion of proBDNF to mature BDNF. Defects in these mechanisms contribute differentially to cognitive dysfunction and anxiety-like behaviors. Here we review recent studies, presented at a symposium at Neuroscience 2009, that describe regulatory mechanisms that permit rapid and dynamic refinement of BDNF actions in neurons.

引用

收藏

页码：12764 / 12767

页数：4

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