Preparation of N-heterocycles by radical cyclisation of enamides mediated by manganese(III) or copper(I).: A comparison of cyclisation methods

被引：68

作者：

Davies, DT

Kapur, N

Parsons, AF ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] SmithKline Beecham Pharmaceut, Dept Med Chem, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 24期

关键词：

manganese and compounds; copper and compounds; cyclisation; enamides;

D O I：

10.1016/S0040-4020(00)00316-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of enamides with manganese(III) acetate or copper(I) chloride/bipyridine has been investigated. In both cases, an initial 5-endo-trig radical cyclisation reaction took place to produce functionalised pyrrolidinones. The copper(I)-mediated cyclisations were very efficient and bicyclic dienes could be isolated in >80% yield, while the corresponding manganese(III) reactions were generally more problematic, giving related dienes in lower yield (35-52%). (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3941 / 3949

页数：9

共 29 条

[1]

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