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IGF-I and IGFBP-3 transport in the rat heart

被引：3
作者：
Boes, M
Dake, BL
Booth, BA
Sandra, A
Bateman, M
Knudtson, KL
Bar, RS
机构：
[1] Univ Iowa, Div Endocrinol, Dept Internal Med, Iowa City, IA 52246 USA
[2] Univ Iowa, Dept Anat & Cell Biol, Iowa City, IA 52246 USA
[3] Univ Iowa, Dept Diabet, Iowa City, IA 52246 USA
[4] Univ Iowa, Endocrinol Res Ctr, Iowa City, IA 52246 USA
[5] Vet Adm Med Ctr, Iowa City, IA 52246 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2003年 / 284卷 / 01期
关键词：
perfused heart; endothelial function; insulin-like growth factor I; insulin-like growth factor-binding protein-3;
D O I：
10.1152/ajpendo.00336.2002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Specific binding of IGF-binding protein (IGFBP)-3 was shown to be present in the isolated, beating rat heart. The uptake of perfused I-125-labeled IGF-I in the beating heart was decreased to 9% by blocking IGF-I binding sites with the IGF-I analog Long R-3 (LR3) IGF-I. When LR3 was perfused with complexes of I-125-IGF-I.IGFBP-3, uptake of I-125-IGF-I was decreased to 41%, which was significantly greater than LR3 and I-125-IGF-I (41 vs. 9%). These data suggest that both microvessel IGF-I and IGFBP-3 binding sites contribute to the transport of IGF-I in the perfused rat heart. This also suggests a novel and plausible mechanism whereby circulating IGFs reach sites of IGF bioactivity.
引用
收藏
页码：E237 / E239
页数：3
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