Synthesis of β-(1 → 6)-linked glucosamine oligosaccharides corresponding to fragments of the bacterial surface polysaccharide poly-N-acetylglucosamine

被引：53

作者：

Gening, Marina L.

Tsvetkov, Yury E.

Pier, Gerald B.

Nifantiev, Nikolay E.

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

来源：

CARBOHYDRATE RESEARCH | 2007年 / 342卷 / 3-4期

关键词：

Staphylococcus aureus; poly-beta-(1 -> 6)-N-acetyl glucosamine; PNAG; oligoglucosamines; convergent synthesis;

D O I：

10.1016/j.carres.2006.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 3-beta-acetamidopropyl oligo-beta-(1 -> 6)-glucosamines consisting of 5, 7, 9 and 11 glucosamine residues, and a series of corresponding per-N-acetylated derivatives were synthesized using a convergent blockwise approach. These compounds represent fragments of a bacterial surface polysaccharide produced by numerous bacterial pathogens, including Staphylococcus aureus, and will be used as models for its biochemical and immunological properties. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：567 / 575

页数：9

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