The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase: A novel function of the CD40-ligand as signalling molecule

被引：27

作者：

Koppenhoefer, U ^{[1
]}

Brenner, B ^{[1
]}

Lang, F ^{[1
]}

Gulbins, E ^{[1
]}

机构：

[1] UNIV TUBINGEN,DEPT PHYSIOL,D-72076 TUBINGEN,GERMANY

来源：

FEBS LETTERS | 1997年 / 414卷 / 02期

关键词：

CD40; ligand; neutral sphingomyelinase; T lymphocyte; tyrosine kinase;

D O I：

10.1016/S0014-5793(97)01035-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1-4]. Here, we provide evidence that activation of T-lymphocytes via CD40L results in activation of a neutral but not an acidic sphingomyelinase correlating with a consumption of sphingomyelin and a release of ceramide. Activation of the neutral sphingomyelinase by the CD40L seems to involve a novel signalling cascade since it is independent of CD40L induced protein kinase activation or association of the neutral sphingomyelinase with the CD40L. (C) 1997 Federation of European Biochemical Societies.

引用

页码：444 / 448

页数：5

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