Acid DNases and their interest among apoptotic endonucleases

被引：46

作者：

Counis, Marie-France ^{[1
]}

Torriglia, Alicia ^{[1
]}

机构：

[1] Ctr Rech Biomed Cordeliers, INSERM, U 598, F-75006 Paris, France

来源：

BIOCHIMIE | 2006年 / 88卷 / 12期

关键词：

apoptosis; DNases; CAD; pH mainly due to NA(+)/H+ exchanger; acidic DNases; DNase II alpha; DNase II beta; L-DNase II;

D O I：

10.1016/j.biochi.2006.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is characterized by cell shrinkage, nuclear condensation and internucleosomal DNA cleavage. Besides the central role of caspases and other proteases, cell death triggers DNA degradation so that DNases have an active role in apoptotic cell death. The best-characterized apoptotic DNase is CAD, a neutral Mg-dependent endonuclease. Its activity is regulated by its inhibitor, ICAD, which is cleaved by caspases. Other neutral DNases have been shown to cleave nuclear DNA in apoptotic conditions: endonuclease G, GADD. In cells, the cytosolic pH is maintained to 7.2, mostly due to the activity of the Na+/H+ exchanger. In many apoptotic conditions, a decrease of the intracellular pH has been shown. This decrease may activate different acid DNases, mostly when pH decreases below 6.5. Three acidic DNases 11 are so far known: DNase 11 a, DNase 11 P and L-DNase 11, a DNase 11, derived from the serpin LEI (Leukocyte Elastase Inhibitor). Their activation during cell death is discussed in this review. (c) 2006 Elsevier Masson SAS. All rights reserved.

引用

页码：1851 / 1858

页数：8

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