Increasing Incidence of Post-Kala-Azar Dermal Leishmaniasis in a Population-Based Study in Bangladesh

被引：74

作者：

Rahman, Kazi Mizanur

Islam, Shamim

Rahman, Muhammad Waliur

Kenah, Eben ^{[3
]}

Galive, Chowdhury Mohammad

Zahid, M. M.

Maguire, James ^{[4
]}

Rahman, Mahmudur ^{[2
]}

Haque, Rashidul

Luby, Stephen P.

Bern, Caryn ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Parasit Dis, Atlanta, GA 30341 USA

[2] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh

[3] Univ Washington, Seattle, WA 98195 USA

[4] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 50卷 / 01期

基金：

美国国家卫生研究院;

关键词：

VISCERAL LEISHMANIASIS; EPIDEMIOLOGY; SITUATION; IMPACT;

D O I：

10.1086/648727

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Post-kala-azar dermal leishmaniasis (PKDL) occurs after kala-azar treatment and acts as a durable infection reservoir. On the basis of active case finding among 22,699 respondents, 813 (3.6%) had had kala-azar since 2002, of whom 79 (9.7%) developed PKDL. Eight additional patients with PKDL had no history of kala-azar. Annual kala-azar incidence peaked at 85 cases per 10,000 person-years in 2004 and fell to 46 cases per 10,000 person-years in 2007, but PKDL incidence rose from 1 case per 10,000 person-years in 2002-2004 to 21 cases per 10,000 person-years in 2007. The rising PKDL incidence threatens the regional visceral leishmaniasis elimination initiative and underscores the urgent need for more effective PKDL diagnosis and treatment.

引用

页码：73 / 76

页数：4

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