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The development of androgen-independent prostate cancer

被引：1887
作者：
Feldman, BJ [1 ]
Feldman, D [1 ]
机构：
[1] Stanford Univ, Sch Med, Div Endocrinol, Dept Med, Stanford, CA 94305 USA
来源：
NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期
关键词：
D O I：
10.1038/35094009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. Cancers that are not cured by surgery eventually become androgen independent, rendering anti-androgen therapy ineffective. But how does androgen independence arise? We predict that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present, untreatable cancers.
引用
收藏
页码：34 / 45
页数：12
相关论文
共 99 条
  • [1] Androgen-insensitivity syndrome as a possible coactivator disease
    Adachi, M
    Takayanagi, R
    Tomura, A
    Imasaki, K
    Kato, S
    Goto, K
    Yanase, T
    Ikuyama, S
    Nawata, H
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (12) : 856 - 862
  • [2] Agus DB, 1999, CANCER RES, V59, P4761
  • [3] Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1α with multiple steroid receptors and identification of an internally deleted ELE1β isoform
    Alen, P
    Claessens, F
    Schoenmakers, E
    Swinnen, JV
    Verhoeven, G
    Rombauts, W
    Peeters, B
    [J]. MOLECULAR ENDOCRINOLOGY, 1999, 13 (01) : 117 - 128
  • [4] AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
    Anzick, SL
    Kononen, J
    Walker, RL
    Azorsa, DO
    Tanner, MM
    Guan, XY
    Sauter, G
    Kallioniemi, OP
    Trent, JM
    Meltzer, PS
    [J]. SCIENCE, 1997, 277 (5328) : 965 - 968
  • [5] ERBB2 AMPLIFICATION IS ASSOCIATED WITH TAMOXIFEN RESISTANCE IN STEROID-RECEPTOR POSITIVE BREAST-CANCER
    BORG, A
    BALDETORP, B
    FERNO, M
    KILLANDER, D
    OLSSON, H
    RYDEN, S
    SIGURDSSON, H
    [J]. CANCER LETTERS, 1994, 81 (02) : 137 - 144
  • [6] Mechanisms of androgen receptor activation and function
    Brinkmann, AO
    Blok, LJ
    de Ruiter, PE
    Doesburg, P
    Steketee, K
    Berrevoets, CA
    Trapman, J
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1999, 69 (1-6) : 307 - 313
  • [7] Bruchovsky N, 2000, MOL UROL, V4, P191
  • [8] Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function
    Buchanan, G
    Yang, MO
    Harris, JM
    Nahm, HS
    Han, GZ
    Moore, N
    Bentel, JM
    Matusik, RJ
    Horsfall, DJ
    Marshall, VR
    Greenberg, NM
    Tilley, WD
    [J]. MOLECULAR ENDOCRINOLOGY, 2001, 15 (01) : 46 - 56
  • [9] Buchanan G, 2001, CLIN CANCER RES, V7, P1273
  • [10] Stem cell genes in androgen-independent prostate cancer
    Bui, M
    Reiter, RE
    [J]. CANCER AND METASTASIS REVIEWS, 1998, 17 (04) : 391 - 399
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