Bcl6 Mediates the Development of T Follicular Helper Cells

被引：1182

作者：

Nurieva, Roza I. ^{[1
]}

Chung, Yeonseok ^{[1
]}

Martinez, Gustavo J. ^{[1
]}

Yang, Xuexian O. ^{[1
]}

Tanaka, Shinya ^{[1
]}

Matskevitch, Tatyana D. ^{[1
]}

Wang, Yi-Hong ^{[1
]}

Dong, Chen ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

SCIENCE | 2009年 / 325卷 / 5943期

关键词：

GERMINAL-CENTER FORMATION; ROR-GAMMA; DIFFERENTIATION; INTERLEUKIN-21; INFLAMMATION; GENERATION; EXPRESSION; RESPONSES; LINEAGE;

D O I：

10.1126/science.1176676

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A fundamental function of CD4(+) helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of T(H)1, T(H)2, and T(H)17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH) cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced T(FH)-related gene expression and inhibited other T(H) lineage cell differentiation in a DNA binding-dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired T(FH) cell development and germinal center reactions, and altered production of other effector T cell subsets. Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation.

引用

页码：1001 / 1005

页数：5

共 16 条

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