A model of the endogenous glucose balance incorporating the characteristics of glucose transporters

被引：16

作者：

Arleth, T

Andreassen, S

Federici, MO

Benedetti, MM

机构：

[1] Univ Aalborg, Dept Med Informat, Inst 8, DK-9100 Aalborg, Denmark

[2] Univ Perugia, Dept Internal Med & Endocrine & Metab Sci, I-06100 Perugia, Italy

来源：

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE | 2000年 / 62卷 / 03期

关键词：

endogenous glucose balance; glucose transporters; insulin; DIAS system;

D O I：

10.1016/S0169-2607(00)00069-9

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

This paper describes the development and preliminary test of a model of the endogenous glucose balance that incorporates the characteristics of the glucose transporters GLUT1, GLUT3 and GLUT4. In the modeling process the model is parameterized with nine parameters that are subsequently estimated from data in the literature on the hepatic- and endogenous- balances at various combinations of blood glucose and insulin levels. The ability of the resulting endogenous balance to fit blood glucose measured from patients was tested on 20 patients. The fit obtained with this model compared favorably with the fit obtained with the endogenous balance currently incorporated in the DIAS system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：219 / 234

页数：16

共 47 条

[1] LACTATE AND GLUCOSE EXCHANGE ACROSS THE FOREARM, LEGS, AND SPLANCHNIC BED DURING AND AFTER PROLONGED LEG EXERCISE [J].