What is the significance of vascular hydrogen sulphide (H2S)?

被引：14

作者：

O'Sullivan, S. E. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Biomed Sci, Nottingham, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2006年 / 149卷 / 06期

关键词：

hydrogen sulphide; vasorelaxation; vasoconstriction; nitric oxide; vasculature; blood pressure; nitrosothiol;

D O I：

10.1038/sj.bjp.0706907

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The important role of nitric oxide (NO) in the regulation of vascular tone has been well studied. By contrast, the vascular significance of another gaseous mediator, hydrogen sulphide (H2S), is still poorly understood. A study published in this issue of the British Journal of Pharmacology now provides evidence that in addition to the vasorelaxant effects of H2S reported in vitro, low concentrations of H2S also cause arterial vasoconstriction, reverse NO-mediated vasorelaxation and cause an NO-dependent pressor effect in vivo. This commentary discusses the implications and questions raised by these results.

引用

页码：609 / 610

页数：2

共 11 条

[1] Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide? [J].

Ali, M. Y. ;

Ping, C. Y. ;

Mok, Y-Y P. ;

Ling, L. ;

Whiteman, M. ;

Bhatia, M. ;

Moore, P. K. .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 149 (06) :625-634

[2]

ALLEN BW, 2006, BRIT J PHARMACOL, V291, pH1507

[3] Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats [J].

Cheng, YQ ;

Ndisang, JF ;

Tang, GH ;

Cao, K ;

Wang, R .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (05) :H2316-H2323

[4] Calcium-dependent release of NO from intracellular S-nitrosothiols [J].

Chvanov, Michael ;

Gerasimenko, Oleg V. ;

Petersen, Ole H. ;

Tepikin, Alexei V. .

EMBO JOURNAL, 2006, 25 (13) :3024-3032

[5] Vertebrate phylogeny of hydrogen sulfide vasoactivity [J].

Dombkowski, RA ;

Russell, MJ ;

Schulman, AA ;

Doellman, MM ;

Olson, KR .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 288 (01) :R243-R252

[6]

Jiang Hai-long, 2005, Di Yi Jun Yi Da Xue Xue Bao, V25, P951

[7] Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse [J].

Li, L ;

Bhatia, M ;

Zhu, YZ ;

Zhu, YC ;

Ramnath, RD ;

Wang, ZJ ;

Anuar, FBM ;

Whiteman, M ;

Salto-Tellez, M ;

Moore, PK .

FASEB JOURNAL, 2005, 19 (06) :1196-+

[8] Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis [J].

Mok, YYP ;

Atan, MSBM ;

Ping, CY ;

Jing, WZ ;

Bhatia, M ;

Moochhala, S ;

Moore, PK .

BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (07) :881-889

[9] Hydrogen sulfide inhibits nitric oxide production and nuclear factor-κB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide [J].

Oh, Gi-Su ;

Pae, Hyun-Ock ;

Lee, Bok-Soo ;

Kim, Byeong-Narn ;

Kim, Jong-Moon ;

Kim, Hyung-Ryong ;

Jeon, Seon Bok ;

Jeon, Woo Kyu ;

Chae, Han-Jung ;

Chung, Hun-Taeg .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (01) :106-119

[10] Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide [J].

Whiteman, M ;

Li, L ;

Kostetski, I ;

Chu, SH ;

Siau, JL ;

Bhatia, M ;

Moore, PK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 343 (01) :303-310

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