Pharmaceutical and biotechnological aerosols for cystic fibrosis therapy

被引:32
作者
Garcia-Contreras, L [1 ]
Hickey, AJ [1 ]
机构
[1] Univ N Carolina, Sch Pharm, Div Drug Delivery & Disposit, Chapel Hill, NC 27599 USA
关键词
aerosol therapy; pulmonary deposition; particle size; antibiotics; gene therapy;
D O I
10.1016/S0169-409X(02)00159-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This review addresses different aerosol therapies used to treat the underlying cause and symptoms of cystic fibrosis (CF) during the past two decades. A summary of the current methods of aerosol delivery and suggestions that may improve the efficacy of the current treatments are provided. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1491 / 1504
页数:14
相关论文
共 77 条
[1]   RECOMBINANT HUMAN DNASE INHALATION IN NORMAL SUBJECTS AND PATIENTS WITH CYSTIC-FIBROSIS - A PHASE-1 STUDY [J].
AITKEN, ML ;
BURKE, W ;
MCDONALD, G ;
SHAK, S ;
MONTGOMERY, AB ;
SMITH, A .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (14) :1947-1951
[2]   NONINVASIVE LIPOSOME-MEDIATED GENE DELIVERY CAN CORRECT THE ION-TRANSPORT DEFECT IN CYSTIC-FIBROSIS MUTANT MICE [J].
ALTON, EWFW ;
MIDDLETON, PG ;
CAPLEN, NJ ;
SMITH, SN ;
STEEL, DM ;
MUNKONGE, FM ;
JEFFERY, PK ;
GEDDES, DM ;
HART, SL ;
WILLIAMSON, R ;
FASOLD, KI ;
MILLER, AD ;
DICKINSON, P ;
STEVENSON, BJ ;
MCLACHLAN, G ;
DORIN, JR ;
PORTEOUS, DJ .
NATURE GENETICS, 1993, 5 (02) :135-142
[3]  
[Anonymous], PHARM TECH
[4]  
[Anonymous], 1992, DRUGS PHARM SCI
[5]   ACUTE AND LONG-TERM AMILORIDE INHALATION IN CYSTIC-FIBROSIS LUNG-DISEASE - A RATIONAL APPROACH TO CYSTIC-FIBROSIS THERAPY [J].
APP, EM ;
KING, M ;
HELFESRIEDER, R ;
KOHLER, D ;
MATTHYS, H .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (03) :605-612
[6]   EFFICACY OF SALBUTAMOL AND IPRATROPIUM BROMIDE IN DECREASING BRONCHIAL HYPERREACTIVITY IN CHILDREN WITH CYSTIC-FIBROSIS [J].
AVITAL, A ;
SANCHEZ, I ;
CHERNICK, V .
PEDIATRIC PULMONOLOGY, 1992, 13 (01) :34-37
[7]   Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis [J].
Bennett, WD ;
Olivier, KN ;
Zeman, KL ;
Hohneker, KW ;
Boucher, RC ;
Knowles, MR .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (06) :1796-1801
[8]   NEBULIZED AMILORIDE IN RESPIRATORY EXACERBATIONS OF CYSTIC-FIBROSIS - A RANDOMIZED CONTROLLED TRIAL [J].
BOWLER, IM ;
KELMAN, B ;
WORTHINGTON, D ;
LITTLEWOOD, JM ;
WATSON, A ;
CONWAY, SP ;
SMYE, SW ;
JAMES, SL ;
SHELDON, TA .
ARCHIVES OF DISEASE IN CHILDHOOD, 1995, 73 (05) :427-430
[9]   DORNASE ALFA - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC POTENTIAL IN CYSTIC-FIBROSIS [J].
BRYSON, HM ;
SORKIN, EM .
DRUGS, 1994, 48 (06) :894-906
[10]  
CONWAY SP, 1993, PEDIATR PULM, V9, P250