CD3(-)CD4(+) cells with a Th2-like pattern of cytokine production in the peripheral blood of a patient with cutaneous T cell lymphoma

被引：23

作者：

Brugnoni, D ^{[1
]}

Airo, P ^{[1
]}

Tosoni, C ^{[1
]}

Taglietti, M ^{[1
]}

LodiRizzini, F ^{[1
]}

CalzavaraPinton, P ^{[1
]}

Leali, C ^{[1
]}

Cattaneo, R ^{[1
]}

机构：

[1] SPEDALI CIVIL BRESCIA, DERMATOL CLIN, I-25100 BRESCIA, ITALY

来源：

LEUKEMIA | 1997年 / 11卷 / 11期

关键词：

Th2; cytokines; cutaneous T cell lymphoma; CD3(-)CD4(+) cells;

D O I：

10.1038/sj.leu.2400839

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case of cutaneous T cell lymphoma associated with mild eosinophilia and rise of IgE levels is reported. A population of CD3(-)CD4(+) cells was observed in the peripheral blood. After activation, these purified CD3(-)CD4(+) cells showed a Th2 pattern of cytokine production, secreting higher levels of IL-5 and IL-4 and lower levels of IFN-gamma compared to the patient's and controls' CD3(+)CD4(+) cells. Moreover, high levels of IL-5 and soluble CD30, a marker of Th2 cell activation, were detected in the patient's serum.

引用

页码：1983 / 1985

页数：3

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