Structural Mechanisms for Regulation of Membrane Traffic by Rab GTPases

被引：105

作者：

Lee, Meng-Tse Gabe

Mishra, Ashwini

Lambright, David G. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

来源：

TRAFFIC | 2009年 / 10卷 / 10期

关键词：

effector; GAP; GDF; GDI; GEF; membrane traffic; Rab GTPase; REP; structure; TBC domain; Vps9; domain; GUANINE-NUCLEOTIDE-EXCHANGE; GDP-DISSOCIATION INHIBITOR; DOMAIN-CONTAINING PROTEINS; ACTIVATING PROTEIN; CRYSTAL-STRUCTURE; GTP HYDROLYSIS; ENDOPLASMIC-RETICULUM; RAB6-INTERACTING PROTEIN-1; TRAPP COMPLEX; FAMILY;

D O I：

10.1111/j.1600-0854.2009.00942.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In all eukaryotic organisms, Rab GTPases function as critical regulators of membrane traffic, organelle biogenesis and maturation, and related cellular processes. The numerous Rab proteins have distinctive yet overlapping subcellular distributions throughout the endomembrane system. Intensive investigation has clarified the underlying molecular and structural mechanisms for several ubiquitous Rab proteins that control membrane traffic between tubular-vesicular organelles in the exocytic, endocytic and recycling pathways. In this review, we focus on structural insights that inform our current understanding of the organization of the Rab family as well as the mechanisms for membrane targeting and activation, interaction with effectors, deactivation and specificity determination.

引用

页码：1377 / 1389

页数：13

共 116 条

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