Bosentan and sildenafil: Should the combination therapy be a valid alternative in childhood to prostacyclin infusion?

被引:7
作者
Brancaccio, Gianluca
Toscano, Alessandra
Bevilacqua, Maurizio
Di Chiara, Luca
Parisi, Francesco
机构
[1] Osped Pediat Bambino Gesu, Dept Cardiac Surg, I-00165 Rome, Italy
[2] Osped Pediat Bambino Gesu, Dept Pediat Cardiol, I-00165 Rome, Italy
关键词
pulmonary arterial hypertension; bosentan; sildenafil;
D O I
10.1111/j.1399-3046.2006.00606.x
中图分类号
R72 [儿科学];
学科分类号
100202 [儿科学];
摘要
We report a case of a seven-yr-old girl with a PAH treated with continuation therapy of bosentan and sildenafil. The combination therapy revealed safety and efficacy in long-term follow up.
引用
收藏
页码:110 / 112
页数:3
相关论文
共 18 条
[1]
Vasodilator therapy for primary pulmonary hypertension in children [J].
Barst, RJ ;
Maislin, G ;
Fishman, AP .
CIRCULATION, 1999, 99 (09) :1197-1208
[2]
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension [J].
Barst, RJ ;
Rubin, LJ ;
Long, WA ;
McGoon, MD ;
Rich, S ;
Badesch, DB ;
Groves, BM ;
Tapson, VF ;
Bourge, RC ;
Brundage, BH ;
Koerner, SK ;
Langleben, D ;
Keller, CA ;
Murali, S ;
Uretsky, BF ;
Clayton, LM ;
Jobsis, MM ;
Blackburn, SD ;
Shortino, D ;
Crow, JW .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :296-301
[3]
SURVIVAL IN PATIENTS WITH PRIMARY PULMONARY-HYPERTENSION - RESULTS FROM A NATIONAL PROSPECTIVE REGISTRY [J].
DALONZO, GE ;
BARST, RJ ;
AYRES, SM ;
BERGOFSKY, EH ;
BRUNDAGE, BH ;
DETRE, KM ;
FISHMAN, AP ;
GOLDRING, RM ;
GROVES, BM ;
KERNIS, JT ;
LEVY, PS ;
PIETRA, GG ;
REID, LM ;
REEVES, JT ;
RICH, S ;
VREIM, CE ;
WILLIAMS, GW ;
WU, M .
ANNALS OF INTERNAL MEDICINE, 1991, 115 (05) :343-349
[4]
Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension [J].
Galiè, N ;
Seeger, W ;
Naeije, R ;
Simonneau, G ;
Rubin, LJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (12) :81S-88S
[5]
Guidelines on diagnosis and treatment of pulmonary arterial hypertension -: The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology [J].
Galiè, N ;
Torbicki, A ;
Barst, R ;
Dartevelle, P ;
Haworth, S ;
Higenbottam, T ;
Olschewski, H ;
Peacock, A ;
Pietra, G ;
Rubin, LJ ;
Simonneau, G .
EUROPEAN HEART JOURNAL, 2004, 25 (24) :2243-2278
[6]
Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension [J].
Hoeper, MM ;
Faulenbach, C ;
Golpon, H ;
Winkler, J ;
Welte, T ;
Niedermeyer, J .
EUROPEAN RESPIRATORY JOURNAL, 2004, 24 (06) :1007-1010
[7]
Goal-oriented treatment and combination therapy for pulmonary arterial hypertension [J].
Hoeper, MM ;
Markevych, I ;
Spiekerkoetter, E ;
Welte, T ;
Niedermeyer, J .
EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (05) :858-863
[8]
HOEPER MM, 2002, AM J RESP CRIT CARE, V40, P780
[9]
Safety and efficacy of Sildenafil therapy in children with pulmonary hypertension [J].
Karatza, AA ;
Bush, A ;
Magee, AG .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 100 (02) :267-273
[10]
Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension [J].
Michelakis, ED ;
Tymchak, W ;
Noga, M ;
Webster, L ;
Wu, XC ;
Lien, D ;
Wang, SH ;
Modry, D ;
Archer, SL .
CIRCULATION, 2003, 108 (17) :2066-2069