The immune response during acute HIV-1 infection: clues for vaccine development

被引：629

作者：

McMichael, Andrew J. ^{[1
]}

Borrow, Persephone ^{[2
]}

Tomaras, Georgia D. ^{[3
]}

Goonetilleke, Nilu ^{[1
]}

Haynes, Barton F. ^{[3
]}

机构：

[1] Univ Oxford, Weatherall Inst Mol Med, MRC, Human Immunol Unit, Oxford OX3 9DS, England

[2] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England

[3] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSES; PLASMACYTOID DENDRITIC CELL; VIRAL SET-POINT; NEUTRALIZING ANTIBODY; VAGINAL TRANSMISSION; DISEASE PROGRESSION; LYMPHOCYTE ESCAPE; MAJOR DETERMINANTS; PREDICTIVE-VALUE; GP41; ANTIBODIES;

D O I：

10.1038/nri2674

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The early immune response to HIV-1 infection is likely to be an important factor in determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies that arise following a mucosal infection are usually derived from a single transmitted virus. Moreover, the finding that the first effective immune responses drive the selection of virus escape mutations provides insight into the earliest immune responses against the transmitted virus and their contributions to the control of acute viraemia. Strong innate and adaptive immune responses occur subsequently but they are too late to eliminate the infection. In this Review, we discuss recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine.

引用

页码：11 / 23

页数：13

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