Rhodium-catalysed racemisation of N-acyl α-amino acids

被引：12

作者：

Hateley, MJ ^{[1
]}

Schichl, DA ^{[1
]}

Kreuzfeld, HJ ^{[1
]}

Beller, M ^{[1
]}

机构：

[1] Univ Rostock eV, Inst Organ Katalyseforsch, D-18055 Rostock, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期

关键词：

racemisation; rhodium; tricyclohexylphosphine; N-acyl alpha-amino acids;

D O I：

10.1016/S0040-4039(00)00539-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first transition metal-catalysed racemisation of N-acyl alpha-amino acids, which is of importance for kinetic resolution processes, is described. Enantiomerically pure N-acyl cx-amino acids were efficiently racemised under mild conditions using various rhodium complexes as catalysts, e.g. [Rh(cod)Cl](2), in the presence of phosphines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3821 / 3824

页数：4

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