Exploring privileged structures: the combinatorial synthesis of cyclic peptides

被引：84

作者：

Horton, DA

Bourne, GT

Smythe, ML ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[2] Univ Queensland, Protagonist Pty Ltd, Gehrmann Labs Level 7, St Lucia, Qld 4072, Australia

来源：

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | 2002年 / 16卷 / 5-6期

关键词：

combinatorial chemistry; cyclic peptide; diketopiperazine; library synthesis; piperazine-2,5-dione; privileged structure; ring contraction; solid-phase;

D O I：

10.1023/A:1020863921840

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be considered to be privileged structures. This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries. It also briefly outlines some of the biological applications of these molecules, thereby justifying their inclusion as privileged structures.

引用

页码：415 / 430

页数：16

共 187 条

[1] Design and synthesis of novel scaffolds for drug discovery:: Hybrids of β-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one, the corresponding 1-oxazepine, and 2-and 4-pyridyldiazepines [J].