Unique maturation program of the IgE response in vivo

被引:178
作者
Erazo, Agustin
Kutchukhidze, Nino
Leung, Monica
Christ, Ana P. Guarnieri
Urban, Joseph F., Jr.
de Lafaille, Maria A. Curotto [1 ]
Lafaille, Juan J.
机构
[1] NYU, Sch Med, Program Mol Pathogenesis, Skirball Inst Biomol Med, New York, NY 10016 USA
[2] NYU, Sch Med, Sackler Inst Grad Biomed Sci, New York, NY 10016 USA
[3] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
[4] Univ Sao Paulo, Dept Immunol, BR-05508900 Sao Paulo, Brazil
[5] USDA ARS, Beltsville Human Nutr Res Ctr, Nutrient Requirements & Funct Lab, Beltsville, MD 20705 USA
关键词
D O I
10.1016/j.immuni.2006.12.006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A key event in the pathogenesis of asthma and allergies is the production of IgE antibodies. We show here that IgE(+) cells were exceptional because they were largely found outside germinal centers and expressed, from very early on, a genetic program of plasma cells. In spite of their extragerminal center localization, IgE(+) cells showed signs of somatic hypermutation and affinity maturation. We demonstrated that high-affinity IgE(+) cells could be generated through a unique differentiation program that involved two phases: a pre-IgE phase in which somatic hypermutation and affinity maturation take place in IgG1(+) cells, and a post-IgE-switching phase in which IgE cells differentiate swiftly into plasma cells. Our results have implications for the understanding of IgE memory responses in allergy.
引用
收藏
页码:191 / 203
页数:13
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