Selection of colistin-resistant Acinetobacter baumannii isolates in postneurosurgical meningitis in an intensive care unit with high presence of heteroresistance to colistin

被引：97

作者：

Carlos Hernan, Rodriguez ^{[1
]}

Karina, Bombicino ^{[1
]}

Gabriela, Granados ^{[1
]}

Marcela, Nastro ^{[1
]}

Carlos, Vay ^{[1
]}

Angela, Famiglietti ^{[1
]}

机构：

[1] Univ Buenos Aires, Bacteriol Lab, Dept Bioquim Clin, Hosp Clin Jose de San Martin,Fac Farm & Bioquim, RA-1120 Buenos Aires, DF, Argentina

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 65卷 / 02期

关键词：

Acinetobacter; Colistin; Heteroresistance to colistin; POLYMYXIN-B; EMERGENCE; STRAINS;

D O I：

10.1016/j.diagmicrobio.2009.05.019

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Colistin heteroresistance in Acinetobacter baumanni (Ab) has been reported, but the clinical impact and the antimicrobial treatment have not been established yet. We observed the selection intratreatment with colistin of Ab colistin-resistant strains from a colistin-heteroresistant isolate in one patient with postneurosurgical meningitis. The presence and the genetic relationship of heteroresistant Ab isolates from intensive care units (ICUs) obtained in the same period of the case report were analyzed. Twenty-eight isolates from patients admitted to the ICUs of an Argentinian university hospital during June to December 2004 were evaluated. Genomoespecie was determined by amplified ribosomal DNA restriction analysis, and genetic similarity among the strains was determined by pulsed-field electrophoresis. Colistin heteroresistance was observed in 46, 4% of these isolates. The majority belonged to clones previously identified as I and Ill. (C) 2009 Published by Elsevier Inc.

引用

页码：188 / 191

页数：4

共 21 条

[1] In vitro activities of nontraditional antimicrobials against multiresistant Acinetobacter baumannii strains isolated in an intensive care unit outbreak [J].