β-Lactamases- the Threat Renews

被引：25

作者：

Livermore, David M. ^{[1
]}

机构：

[1] Hlth Protect Agcy Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London NW9 5EQ, England

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2009年 / 10卷 / 05期

关键词：

Penicillin; beta-lactamase; antibiotic resistance; SITE-DIRECTED MUTAGENESIS; STAPHYLOCOCCUS-AUREUS; CTX-M; ENTEROBACTERIACEAE; BACTEREMIA; RESISTANCE; EMERGENCE; THERAPY; CARBAPENEMASES; CEPHALOSPORIN;

D O I：

10.2174/138920309789351994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-Lactamases are the greatest single source of resistance to beta-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new beta-lactam analogues are introduced but then select for new beta-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM-1 enzyme and modern oxymino cephalosporins by "extended-spectrum" beta-lactamases. Tony Fink's work contributed greatly to our understanding of the mechanisms and active site function of beta-lactamases and this knowledge now informs the search for new beta-lactams and beta-lactamase inhibitors.

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收藏

页码：397 / 400

页数：4

相关论文

共 33 条

[1] An enzyme from bacteria able to destroy penicillin [J].

Abraham, EP ;

Chain, E .

NATURE, 1940, 146 :837-837

[2]

ANDERSON ES, 1965, LANCET, V1, P407

[3]

BARBER M, 1948, LANCET, V2, P641

[4] Epidemiology of methicillin-resistant Staphylococcus aureus [J].

Boucher, Helen W. ;

Corey, G. Ralph .

CLINICAL INFECTIOUS DISEASES, 2008, 46 :S344-S349

[5] ISOLATION OF A COVALENT INTERMEDIATE IN BETA-LACTAMASE-I CATALYSIS [J].

CARTWRIGHT, SJ ;

FINK, AL .

FEBS LETTERS, 1982, 137 (02) :186-188

[6] Rapid emergence of blaCTX-M among Enterobacteriaceae in US medical centers:: Molecular evaluation from the MYSTIC program (2007) [J].

Castanheira, Mariana ;

Mendes, Rodrigo E. ;

Rhomberg, Paul R. ;

Jones, Ronald N. .

MICROBIAL DRUG RESISTANCE, 2008, 14 (03) :211-216

[7] MULTICENTER SURVEY OF THE COMPARATIVE IN-VITRO ACTIVITY OF PIPERACILLIN TAZOBACTAM AGAINST BACTERIA FROM HOSPITALIZED-PATIENTS IN THE BRITISH-ISLES [J].

CHEN, HY ;

BONFIGLIO, G ;

ALLEN, M ;

PIPER, D ;

EDWARDSON, T ;

MCVEY, D ;

LIVERMORE, DM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 32 (02) :247-266

[8] ENTEROBACTER BACTEREMIA - CLINICAL-FEATURES AND EMERGENCE OF ANTIBIOTIC-RESISTANCE DURING THERAPY [J].

CHOW, JW ;

FINE, MJ ;

SHLAES, DM ;

QUINN, JP ;

HOOPER, DC ;

JOHNSON, MP ;

RAMPHAL, R ;

WAGENER, MM ;

MIYASHIRO, DK ;

YU, VL .

ANNALS OF INTERNAL MEDICINE, 1991, 115 (08) :585-590

[9] Health and economic outcomes of the emergence of third-generation cephalosporin resistance in Enterobacter species [J].

Cosgrove, SE ;

Kaye, KS ;

Eliopoulous, GM ;

Carmeli, Y .

ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (02) :185-190

[10] THE ROLE OF LYSINE-234 IN BETA-LACTAMASE CATALYSIS PROBED BY SITE-DIRECTED MUTAGENESIS [J].

ELLERBY, LM ;

ESCOBAR, WA ;

FINK, AL ;

MITCHINSON, C ;

WELLS, JA .

BIOCHEMISTRY, 1990, 29 (24) :5797-5806

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