A helping hand for cytochrome P450 enzymes

被引：22

作者：

DeBose-Boyd, Russell A. ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA

来源：

CELL METABOLISM | 2007年 / 5卷 / 02期

关键词：

HEME-BINDING PROTEIN; FISSION YEAST; IDENTIFICATION; EXPRESSION; STEROLS; CELLS;

D O I：

10.1016/j.cmet.2007.01.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities. This action indicates an important role for Dap1/PGRMC1 in P450-catalyzed reactions, some of which are involved in the metabolism of sterols and pharmaceutical compounds.

引用

页码：81 / 83

页数：3

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