Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

被引：316

作者：

Carmena, Mar ^{[1
]}

Ruchaud, Sandrine ^{[1
]}

Earnshaw, William C. ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 06期

关键词：

CHROMOSOMAL PASSENGER COMPLEX; CELL-CYCLE KINASES; POLO-LIKE KINASE-1; A KINASE; INNER CENTROMERE; SPINDLE CHECKPOINT; PHOSPHATASE INHIBITOR-2; MICROTUBULE DYNAMICS; MITOTIC CHROMOSOMES; ACTIVATION;

D O I：

10.1016/j.ceb.2009.09.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The conserved Aurora family of protein kinases have emerged as crucial regulators of mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very distinctive localisations and functions: Aurora A associates with the spindle poles to regulate entry into mitosis, centrosome maturation and spindle assembly; Aurora B is a member of the Chromosomal Passenger Complex (CPC) that transfers from the inner centromere in early mitosis to the spindle midzone, equatorial cortex and midbody in late mitosis and cytokinesis. Aurora B functions include regulation of chromosome-microtubule interactions, cohesion, spindle stability and cytokinesis. This review will focus on how interacting proteins make this functional diversity possible by targeting the kinases to different subcellular locations and regulating their activity.

引用

页码：796 / 805

页数：10

共 128 条

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