Cerebellar involvement in motor learning

被引:8
作者
Mauk, MD
Steele, PM
Medina, JF
机构
[1] Dept. of Neurobiology and Anatomy, Univ. of Texas Med. Sch. at Houston, Houston, TX
[2] Dept. of Neurobiology and Anatomy, Univ. of Texas Med. Sch. at Houston, Houston, TX 77030
关键词
climbing fiber; nictitating; eyelid conditioning; associative; long-term depression; long-term potentiation;
D O I
10.1177/107385849700300512
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
For decades, cerebellar research has been guided by the central hypothesis that plasticity at synapses in the cerebellar cortex mediates motor learning. This hypothesis has been challenged especially strongly in recent years by data that contradict the original theories of cerebellar motor learning, These data form the basis for strong arguments to the contrary and have inspired new, non-motor theories of cerebellar function. We consider key data that are contrary to the motor learning hypothesis and develop the argument that both old and new data are best explained by extending, rather than rejecting, the basic tenets of the original motor learning theories of cerebellar function.
引用
收藏
页码:303 / 313
页数:11
相关论文
共 48 条
[1]  
ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
[2]  
[Anonymous], 1958, PHYSL PATHOLOGY CERE
[3]  
BLOEDEL JR, 1981, HDB PHYSL NERVOUS SY, P877
[4]   VARIABILITY IN TACTILE PROJECTION PATTERNS TO CEREBELLAR FOLIA CRUS-IIA OF THE NORWAY RAT [J].
BOWER, JM ;
KASSEL, J .
JOURNAL OF COMPARATIVE NEUROLOGY, 1990, 302 (04) :768-778
[5]  
BOWER JM, 1997, IN PRESS PROG BRAIN
[6]   THE CEREBELLUM CONTRIBUTES TO MENTAL SKILLS [J].
BRACKETOLKMITT, R ;
LINDEN, A ;
CANAVAN, AGM ;
ROCKSTROH, B ;
SCHOLZ, E ;
WESSEL, K ;
DIENER, HC .
BEHAVIORAL NEUROSCIENCE, 1989, 103 (02) :442-446
[7]   TEMPORAL SPECIFICITY OF LONG-TERM DEPRESSION IN PARALLEL FIBER-PURKINJE SYNAPSES IN RAT CEREBELLAR SLICE [J].
CHEN, C ;
THOMPSON, RF .
LEARNING & MEMORY, 1995, 2 (3-4) :185-198
[8]   EFFECTS OF ELECTRICAL-STIMULATION AND REVERSIBLE LESIONS OF THE OLIVOCEREBELLAR PATHWAY ON PURKINJE-CELL ACTIVITY IN THE FLOCCULUS OF THE CAT [J].
DEMER, JL ;
ECHELMAN, DA ;
ROBINSON, DA .
BRAIN RESEARCH, 1985, 346 (01) :22-31
[9]  
DeSchutter E, 1996, CURR OPIN NEUROBIOL, V6, P759
[10]   CEREBELLAR LONG-TERM DEPRESSION MIGHT NORMALIZE EXCITATION OF PURKINJE-CELLS - A HYPOTHESIS [J].
DESCHUTTER, E .
TRENDS IN NEUROSCIENCES, 1995, 18 (07) :291-295