EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1

被引：143

作者：

Cheng, SK ^{[1
]}

Olale, F

Bennett, JT

Brivanlou, AH

Schier, AF

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, Dev Genet Program,Dept Cell Biol, New York, NY 10016 USA

[2] Rockefeller Univ, Lab Mol Vertebrate Embryol, New York, NY 10021 USA

来源：

GENES & DEVELOPMENT | 2003年 / 17卷 / 01期

关键词：

TGF-beta; EGF-CFC; Nodal; Activin receptors; mesoderm induction; left-right axis;

D O I：

10.1101/gad.1041203

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The TGF-beta signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction and left-right patterning. Nodal and Activin both activate Activin receptors, but only Nodal requires EGF-CFC coreceptors for signaling. We report that Vg1 and GDF1 signaling in zebrafish also depends on EGF-CFC proteins, but not on Nodal signals. Correspondingly, we find that in Xenopus Vg1 and GDF1 bind to and signal through Activin receptors only in the presence of EGF-CFC proteins. These results establish that multiple TGF-beta signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-beta signaling than anticipated previously.

引用

页码：31 / 36

页数：6

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