Recombinant human immunodeficiency viruses type 1 circulating in Spain

被引：26

作者：

Holguín, A ^{[1
]}

Rodés, B ^{[1
]}

Soriano, V ^{[1
]}

机构：

[1] Inst Salud Carlos III, Infect Dis Serv, Hosp Carlos 3, Madrid 28010, Spain

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2000年 / 16卷 / 05期

关键词：

D O I：

10.1089/088922200309179

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The protease, reverse transcriptase (RT), and envelope (env) genes of human immunodeficiency virus type 1 (HIV-1) clinical isolates from 13 immigrants (mainly of African origin) living in Spain were examined. Phylogenetic analyses were performed, taking as reference a panel of 25 HN-l sequences representing various subtypes. A discrepant topology was recognized in comparing the protease, RT, and/or env phylogenetic trees in 10 isolates, in which sequences clustering in 2 or 3 different HIV-1 subtypes were found. In eight of these strains, the discrepant region was env with respect to concordant pol genes. Five of nine patients harboring subtype G sequences at the protease and RT genes showed discrepant env sequences, being subtype A (three) or B (two). In addition, one recombinant WA strain, one recombinant WE isolate, and a triple recombinant, A/D/C, variant were found. This work represents the first phylogenetic characterization of HIV-1 recombinant clinical isolates in Spain.

引用

页码：505 / 511

页数：7

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