Heart regeneration in zebrafish

被引：1397

作者：

Poss, KD ^{[1
]}

Wilson, LG ^{[1
]}

Keating, MT ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst,Dept Cell Biol,Dept Cardio, Boston, MA 02115 USA

来源：

SCIENCE | 2002年 / 298卷 / 5601期

关键词：

D O I：

10.1126/science.1077857

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection. Regeneration occurs through robust proliferation of cardiomyocytes localized at the leading epicardial edge of the new myocardium. The hearts of zebrafish with mutations in the Mps1 mitotic checkpoint kinase, a critical cell cycle regulator, failed to regenerate and formed scars. Thus, injury-induced cardiomyocyte proliferation in zebrafish can overcome scar formation, allowing cardiac muscle regeneration. These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration.

引用

页码：2188 / 2190

页数：4

共 18 条

[1] Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint [J].