Role of the mouse ank gene in control of tissue calcification and arthritis

被引：500

作者：

Ho, AM

Johnson, MD

Kingsley, DM ^{[1
]}

机构：

[1] Stanford Univ, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Sch Med, Beckman Ctr B300, Stanford, CA 94305 USA

来源：

SCIENCE | 2000年 / 289卷 / 5477期

关键词：

D O I：

10.1126/science.289.5477.265

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank Locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.

引用

页码：265 / 270

页数：6

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