Moexipril for Treatment of Primary Biliary Cirrhosis in Patients with an Incomplete Response to Ursodeoxycholic Acid

被引：24

作者：

Charatcharoenwitthaya, Phunchai ^{[1
]}

Talwalkar, Jayant A. ^{[1
]}

Angulo, Paul ^{[1
]}

Gossard, Andrea A. ^{[1
]}

Keach, Jill C. ^{[1
]}

Petz, Janice L. ^{[1
]}

Jorgensen, Roberta A. ^{[1
]}

Lindor, Keith D. ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2010年 / 55卷 / 02期

关键词：

Primary biliary cirrhosis; Angiotensin-converting enzyme inhibitor; Ursodeoxycholic acid; Treatment; QUALITY-OF-LIFE; CONVERTING ENZYME-INHIBITOR; II RECEPTOR ANTAGONIST; CHRONIC LIVER-DISEASE; CHRONIC HEPATITIS-C; CONTROLLED-TRIAL; DOUBLE-BLIND; NONALCOHOLIC STEATOHEPATITIS; BIOCHEMICAL RESPONSE; ACE-INHIBITOR;

D O I：

10.1007/s10620-009-0744-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Blockade of angiotensin II synthesis attenuates hepatic fibrosis in different experimental models of chronic liver injury. We evaluated the safety and efficacy of moexipril, an angiotensin-converting enzyme inhibitor, in patients with primary biliary cirrhosis (PBC) who have had a suboptimal response to ursodeoxycholic acid (UDCA). Twenty PBC patients on UDCA (13-15 mg/kg/day) therapy with an elevation of serum alkaline phosphatase at least twice the upper limit of normal were treated with oral moexipril 15 mg/day for one year. No significant changes in serum alkaline phosphatase (379 +/- 32 vs. 379 +/- 51), bilirubin (0.8 +/- 0.1 vs. 0.9 +/- 0.1), aspartate aminotransferase (60 +/- 8 vs. 63 +/- 9), and Mayo risk score (3.55 +/- 0.2 vs. 3.62 +/- 0.2) was associated with the treatment. Fatigue and health-related quality of life scores during treatment demonstrated a trend toward improvement. Moexipril was not clinically beneficial to PBC patients responding suboptimally to UDCA.

引用

页码：476 / 483

页数：8

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