Genetics of ventral forebrain development and holoprosencephaly

被引：214

作者：

Muenke, M

Beachy, PA

机构：

[1] Natl Human Genome Res Inst, Med Genet Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[3] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[4] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA

[5] Johns Hopkins Univ, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(00)00084-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The disease holoprosencephaly is the basis of the most common structural anomaly of the developing forebrain in humans. Numerous teratogens when administered during early gastrulation, have been associated with this condition. Recent studies have characterized molecules expressed in the prechordal plate which are critical for normal brain formation. Perturbation of signaling pathways involving these molecules have been shown to cause holoprosencephaly in humans and other organisms.

引用

页码：262 / 269

页数：8

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