Guaifenesin enhances the analgesic potency of paracetamol in mice

被引:6
作者
Dolezal, T [1 ]
Krsiak, M [1 ]
机构
[1] Charles Univ Prague, Fac Med 3, Dept Pharmacol, Prague 10034, Czech Republic
关键词
paracetamol; guaifenesin; analgesic combinations; writhing; locomotor performance;
D O I
10.1007/s00210-002-0642-y
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Aim of investigation: Guaifenesin is used as an expectorant and it has been reported to possess muscle relaxant and sedative activity. Guaifenesin has been used as a component of composite OTC analgesics containing paracetamol for many years. The aim of our study was to ascertain effects of guaifenesin on paracetamol analgesic activity and locomotor performance. Methods: Antinociceptive efficacy was tested in mice using an acetic acid (0.7%) writhing test. Locomotor performance was tested in rota-rod test and activity cage. All drugs were given orally and tested in mice. Results: In combination with a subeffective dose of guaifenesin (200 mg/kg), the ED50 for paracetamol in the writhing test was significantly lower (82.2 mg/kg) than that of paracetamol administered alone (233.7 mg/kg). Guaifenesin alone did not show an analgesic effect. Guaifenesin did not produce statistically significant locomotor impairment in the rota-rod test at doses enhancing analgesic activity of paracetamol, although there was a trend for decreased locomotor activity in activity cage. Conclusion: The present results indicate that guaifenesin may enhance analgesic activity of paracetamol.
引用
收藏
页码:551 / 554
页数:4
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