Voriconazole-resistant disseminated Paecilomyces variotii infection in a neutropenic patient with leukaemia on voriconazole prophylaxis

被引:20
作者
Chamilos, Georgios [1 ]
Kontoyiannis, Dimitrios P. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Unit 402,1515 Holcombe Blvd, Houston, TX 77030 USA
关键词
Fungal infection; Paecilomyces; Resistance; Voriconazole;
D O I
10.1016/j.jinf.2005.02.005
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Paecilomyces variotii, an emerging hyalohyphomycetes, has been reported to be susceptible in vitro to voriconazole. We describe a case of disseminated P. variotii infection in a neutropenic child with relapsed leukaemia who was on voriconazole prophylaxis. The P. variotii isolate was resistant to voriconazole in vitro. The patient responded to liposomal amphotericin B. (C) 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:E225 / E228
页数:4
相关论文
共 17 条
[1]   Antifungal susceptibilities of Paecilomyces species [J].
Aguilar, C ;
Pujol, I ;
Sala, J ;
Guarro, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) :1601-1604
[2]  
CASTRO LGM, 1990, J MED VET MYCOL, V28, P15
[3]   In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds [J].
DelPoeta, M ;
Schell, WA ;
Perfect, JR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (08) :1835-1836
[4]   E-test method for testing susceptibilities of Aspergillus spp. to the new triazoles voriconazole and posaconazole and to established antifungal agents:: Comparison with NCCLS broth microdilution method [J].
Espinel-Ingroff, A ;
Rezusta, A .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (06) :2101-2107
[5]   Testing conditions for determination of minimum fungicidal concentrations of new and established antifungal agents for Aspergillus spp.:: NCCLS Collaborative Study [J].
Espinel-Ingroff, A ;
Fothergill, A ;
Peter, J ;
Rinaldi, MG ;
Walsh, TJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (09) :3204-3208
[6]   Successful treatment of Paecilomyces lilacinus endophthalmitis with voriconazole [J].
Garbino, J ;
Ondrusova, A ;
Baligvo, E ;
Lew, D ;
Bouchuiguir-Wafa, K ;
Rohner, P .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2002, 34 (09) :701-703
[7]  
Herbrecht Raoul, 2004, Expert Rev Anti Infect Ther, V2, P485, DOI 10.1586/14787210.2.4.485
[8]  
Hilmarsdóttir I, 2000, SCAND J INFECT DIS, V32, P331, DOI 10.1080/00365540050166063
[9]   Antifungal drug resistance of pathogenic fungi [J].
Kontoyiannis, DP ;
Lewis, RE .
LANCET, 2002, 359 (9312) :1135-1144
[10]   Zygomycosis in a Tertiary-Care Cancer Center in the era of Aspergillus-active antifungal therapy:: A case-control observational study of 27 recent cases [J].
Kontoyiannis, DP ;
Lionakis, MS ;
Lewis, RE ;
Chamilos, G ;
Healy, M ;
Perego, C ;
Safdar, A ;
Kantarjian, H ;
Champlin, R ;
Walsh, TJ ;
Raad, II .
JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (08) :1350-1360