The extracellular adherence protein from Staphylococcus aureus inhibits neutrophil binding to endothelial cells

被引：34

作者：

Haggar, A

Ehrnfelt, C

Holgersson, J

Flock, JI

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Lab Med, Div Clin Bacteriol, S-14186 Huddinge, Sweden

[2] Huddinge Univ Hosp, Karolinska Inst, Dept Lab Med, Div Immunol, S-14186 Huddinge, Sweden

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 10期

关键词：

D O I：

10.1128/IAI.72.10.6164-6167.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Extracellular adherence protein (Eap) from Staphylococcus aureus inhibits the adherence of neutrophils to nonstimulated and tumor necrosis factor alpha-stimulated endothelial cells in both static adhesion assays and flow adhesion assays. Consequently, Eap also impaired their transendothelial migration. During an S. aureus infection, Eap may thus serve to reduce inflammation by inhibiting neutrophil adhesion and extravasation.

引用

收藏

页码：6164 / 6167

页数：4

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