Suppression of false recognition in Alzheimer's disease and in patients with frontal lobe lesions

被引:95
作者
Budson, AE
Sullivan, AL
Mayer, E
Daffner, KR
Black, PM
Schacter, DL
机构
[1] Brigham & Womens Hosp, Dept Neurol, Div Cognit & Behav Neurol, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Smith Coll, Northampton, MA 01063 USA
[5] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA
关键词
Alzheimer's disease; frontal lobes; source monitoring; false recognition; memory;
D O I
10.1093/brain/awf277
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Previous research has shown that patients with Alzheimer's disease show increasing levels of false recognition across five repeated study-test trials of semantic associates. The present study tested the hypotheses that (i) the increasing false recognition was partly due to the frontal lobe dysfunction of patients with Alzheimer's disease, and (ii) a failure of source monitoring was the central mechanism by which frontal lobe dysfunction led to increasing false recognition across trials. In Experiment 1, patients with frontal lobe lesions and controls were examined in the same repeated trials paradigm as that used previously in patients with Alzheimer's disease. Although controls were able to reduce their false recognition across trials, the patients with frontal lobe lesions were not, and instead showed a constant level of elevated false recognition across the study-test trials. In Experiment 2, two groups of patients with Alzheimer's disease and healthy older adult controls were studied: the first group was given a single study session followed by a recognition test, the second group was given five study sessions followed by a single recognition test. Older adults who were exposed to five study lists demonstrated lower levels of false relative to true recognition, whereas patients with Alzheimer's disease in this condition exhibited levels of false recognition elevated to that of their true recognition, even with the source memory confusion of intervening tests eliminated. The authors suggest that impairment in aspects of frontal lobe function, such as verification-inhibition mechanisms, probably contributes to the inability of patients with Alzheimer's disease to suppress their false recognition across repeated trials. Lastly, it is speculated that one way in which the frontal lobes enable normal episodic memory function is by facilitating the suppression of false recognition and other distortions of memory.
引用
收藏
页码:2750 / 2765
页数:16
相关论文
共 89 条
[1]  
[Anonymous], COGNITIVE NEUROPSYCH
[2]  
[Anonymous], TRAIL MAK TEST
[3]  
[Anonymous], HUMAN MEMORY AMNESIA
[4]   Verbal fluency as a prefrontal activation probe:: a validation study using 99mTc-ECD brain SPET [J].
Audenaert, K ;
Brans, B ;
Van Laere, K ;
Lahorte, P ;
Versijpt, J ;
van Heeringen, K ;
Dierckx, R .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (12) :1800-1808
[5]   Attentional control in Alzheimer's disease [J].
Baddeley, AD ;
Baddeley, HA ;
Bucks, RS ;
Wilcock, GK .
BRAIN, 2001, 124 :1492-1508
[6]   THE DECLINE OF WORKING MEMORY IN ALZHEIMERS-DISEASE - A LONGITUDINAL-STUDY [J].
BADDELEY, AD ;
BRESSI, S ;
DELLASALA, S ;
LOGIE, R ;
SPINNLER, H .
BRAIN, 1991, 114 :2521-2542
[7]   Veridical and false memories in healthy older adults and in dementia of the Alzheimer's type [J].
Balota, DA ;
Cortese, MJ ;
Duchek, JM ;
Adams, D ;
Roediger, HL ;
McDermott, KB ;
Yerys, BE .
COGNITIVE NEUROPSYCHOLOGY, 1999, 16 (3-5) :361-384
[8]   RECOGNITION OF FAMILIAR AND UNFAMILIAR MELODIES IN NORMAL AGING AND ALZHEIMERS-DISEASE [J].
BARTLETT, JC ;
HALPERN, AR ;
DOWLING, WJ .
MEMORY & COGNITION, 1995, 23 (05) :531-546
[9]   On the dual effects of repetition on false recognition [J].
Benjamin, AS .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-LEARNING MEMORY AND COGNITION, 2001, 27 (04) :941-947
[10]   A SIMPLE OBJECTIVE TECHNIQUE FOR MEASURING FLEXIBILITY IN THINKING [J].
Berg, Esta A. .
JOURNAL OF GENERAL PSYCHOLOGY, 1948, 39 (01) :15-22