Positron Emission Tomography in Clinical Islet Transplantation

被引：127

作者：

Eriksson, O. ^{[2
,3
]}

Eich, T. ^{[4
]}

Sundin, A. ^{[5
,6
]}

Tibell, A. ^{[1
]}

Tufveson, G. ^{[7
]}

Andersson, H. ^{[8
]}

Felldin, M. ^{[9
]}

Foss, A. ^{[10
]}

Kyllonen, L. ^{[11
]}

Langstrom, B. ^{[12
]}

Nilsson, B. ^{[4
]}

Korsgren, O. ^{[4
]}

Lundgren, T. ^{[1
]}

机构：

[1] Karolinska Inst, Div Transplantat Surg, CLINTEC, Stockholm, Sweden

[2] Univ Hosp, Dept Radiol Oncol & Clin Immunol, Div Radiol, Stockholm, Sweden

[3] GE Healthcare, Uppsala Imanet, Stockholm, Sweden

[4] Univ Hosp, Div Clin Immunol, Dept Radiol Oncol & Clin Immunol, Stockholm, Sweden

[5] Karolinska Univ Hosp, Dept Radiol, Stockholm, Sweden

[6] Univ Uppsala Hosp, Uppsala, Sweden

[7] Univ Uppsala Hosp, Dept Surg Sci, Div Transplantat Surg, Uppsala, Sweden

[8] Malmo Univ Hosp, Dept Nephrol & Transplantat, Malmo, Sweden

[9] Univ Hosp, Dept Transplantat, Gothenburg, Sweden

[10] Rikshosp Radiumhosp Med Ctr, Dept Transplantat Surg, Oslo, Norway

[11] Univ Helsinki, Surg Hosp, Div Transplantat, Helsinki, Finland

[12] Uppsala Univ, Dept Biochem & Organ Chem, Uppsala, Sweden

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2009年 / 9卷 / 12期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Clinical; islet transplantation; positron emission tomography (PET); 18F-fluorodeoxyglucose ([18F]FDG); instant blood-mediated inflammatory reaction (IBMIR); STEROID-FREE IMMUNOSUPPRESSION; DIABETES-MELLITUS; TISSUE FACTOR; FOLLOW-UP; LANGERHANS; CELLS; ENGRAFTMENT; SUPERIOR; PROTOCOL; MODEL;

D O I：

10.1111/j.1600-6143.2009.02844.x

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

A fraction of the islets (23%) were labeled with 18F-fluorodeoxyglucose ([18F]FDG) and carefully mixed with unlabeled islets just prior to intraportal transplantation. The peak radioactivity concentration in the liver was found at 19 min after start of islet infusion and corresponded to only 75% of what was expected, indicating that islets are lost during the transplantation procedure. No accumulation of radioactivity was found in the lungs. A nonphysiological peak of C-peptide was found in plasma during and immediately after transplantation in all subjects. Distribution in the liver was heterogeneous with wide variations in location and concentration. Islets found in areas with concentrations of > 400 IEQ/cc liver tissue varied between 1% and 32% of the graft in different subjects. No side effects attributed to the PET/CT procedure were found. Clinical outcome in all patients was comparable to that previously observed indicating that the [18F]FDG labeling procedure did not harm the islets. The technique has potential to be used to assess approaches to enhance islet survival and engraftment in clinical transplantation.

引用

页码：2816 / 2824

页数：9

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