Genetic susceptibility and the role of hypertension in diabetic nephropathy

被引：21

作者：

Fogarty, DG

Krolewski, AS

机构：

[1] HARVARD UNIV, SCH MED,JOSLIN DIABET CTR,RES DIV, SECT EPIDEMIOL & GENET, BOSTON, MA 02215 USA

[2] BELFAST CITY HOSP, REG NEPHROL UNIT, BELFAST BT9 7AD, ANTRIM, NORTH IRELAND

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 1997年 / 6卷 / 02期

关键词：

D O I：

10.1097/00041552-199703000-00013

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence exists to suggest that some individuals with diabetes have a genetic predisposition to diabetic nephropathy. Cases of nephropathy cluster in families and a parental history of hypertension, cardiovascular disease and diabetes is more common in patients with diabetic nephropathy. Current evidence favours a role for hypertension in the genetic susceptibility to diabetic nephropathy. This review focuses on the recent evidence for genetic susceptibility, the role and mechanisms of hypertension in the predisposition to nephropathy and the potential of a novel sib-pair approach to identify susceptibility genes.

引用

页码：184 / 191

页数：8

共 79 条

[1] The links between cellular Ca2+ and Na+/H+ exchange in the pathophysiology of essential hypertension [J].

Aviv, A .

AMERICAN JOURNAL OF HYPERTENSION, 1996, 9 (07) :703-707

[2] INCREASED SODIUM-LITHIUM COUNTERTRANSPORT ACTIVITY IN RED-CELLS OF IGA NEPHROPATHY PATIENTS [J].

BOERO, R ;

ESPOSTI, ED ;

FABBRI, A ;

GUARENA, C ;

FORNERIS, G ;

QUARELLO, F ;

FUSAROLI, M ;

PICCOLI, G .

KIDNEY INTERNATIONAL, 1991, 40 (06) :1118-1122

[3] IS DIABETIC NEPHROPATHY AN INHERITED COMPLICATION [J].

BORCHJOHNSEN, K ;

NORGAARD, K ;

HOMMEL, E ;

MATHIESEN, ER ;

JENSEN, JS ;

DECKERT, T ;

PARVING, HH .

KIDNEY INTERNATIONAL, 1992, 41 (04) :719-722

[4] Predictors of the progression of renal insufficiency in patients with insulin-dependent diabetes and overt diabetic nephropathy [J].

Breyer, JA ;

Bain, RP ;

Evans, JK ;

Nahman, NS ;

Lewis, EJ ;

Cooper, M ;

McGill, J ;

Berl, T ;

Rohde, R ;

Hunsicker, LG ;

Lachin, J ;

Greenhouse, SW ;

Verme, DA ;

Turlington, TR ;

Burrows, PK ;

Wish, J ;

Sheehan, J ;

Pohl, M ;

Berl, T ;

Santiago, G ;

Hunsicker, L ;

Kern, EFO ;

Lemann, J ;

Blementhal, S ;

Bresnahan, BS ;

Hebert, L ;

Goldfarb, S ;

Kobrin, S ;

Rodby, R ;

Levey, A ;

McLaughlin, M ;

Williams, M ;

McGill, J ;

Whittler, F ;

Rutecki, G ;

Cattran, D ;

Lietz, S ;

Valaitis, D ;

Hano, J ;

Maxwell, D ;

Porush, J ;

Spitalewitz, S ;

Shapiro, K ;

Adler, S ;

Tolchin, N ;

Hoy, W ;

Bernstein, R ;

Svetkey, L ;

Sharon, Z ;

Rausenbaum, B .

KIDNEY INTERNATIONAL, 1996, 50 (05) :1651-1658

[5] DIFFERENTIAL REGULATION OF ANGIOTENSIN PEPTIDE LEVELS IN PLASMA AND KIDNEY OF THE RAT [J].

CAMPBELL, DJ ;

LAWRENCE, AC ;

TOWRIE, A ;

KLADIS, A ;

VALENTIJN, AJ .

HYPERTENSION, 1991, 18 (06) :763-773

[6] SALT SENSITIVITY IN HYPERTENSION - RENAL AND CARDIOVASCULAR IMPLICATIONS [J].

Campese, VM .

HYPERTENSION, 1994, 23 (04) :531-550

[7] LINKAGE OF THE ANGIOTENSINOGEN GENE TO ESSENTIAL-HYPERTENSION [J].

CAULFIELD, M ;

LAVENDER, P ;

FARRALL, M ;

MUNROE, P ;

LAWSON, M ;

TURNER, P ;

CLARK, AJL .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (23) :1629-1633

[8] GENETIC PREDISPOSITION TO HYPERTENSION (AS DETECTED BY NA+/LI+ COUNTERTRANSPORT) AND RISK OF DIABETIC NEPHROPATHY IN CHILDHOOD DIABETES [J].

CHIARELLI, F ;

VERROTTI, A ;

KALTERLEIBOVICI, O ;

LARON, Z ;

MORGESE, G .

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 1994, 30 (06) :547-549

[9]

Cruickshanks KJ, 1996, DIABETES, V45, P791

[10] A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES [J].

DAVIES, JL ;

KAWAGUCHI, Y ;

BENNETT, ST ;

COPEMAN, JB ;

CORDELL, HJ ;

PRITCHARD, LE ;

REED, PW ;

GOUGH, SCL ;

JENKINS, SC ;

PALMER, SM ;

BALFOUR, KM ;

ROWE, BR ;

FARRALL, M ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE, 1994, 371 (6493) :130-136

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