Memory enhancement: the search for mechanism-based drugs

被引：110

作者：

Lynch, G ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Psychiat, Irvine, CA 92612 USA

来源：

NATURE NEUROSCIENCE | 2002年 / 5卷 / Suppl 11期

关键词：

D O I：

10.1038/nn935

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention scores across a broad range of tests and species. Initial clinical results are encouraging. Issues now arise about appropriate applications of candidate drugs and optimal cellular targets for future development.

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页码：1035 / 1038

页数：4

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