Biphasic calcium phosphate coated with poly-D,L-lactide-co-glycolide biomaterial as a bone substitute

被引：29

作者：

Ignjatovic, Nenad

Ninkov, Petar

Ajdukovic, Zorica

Vasijevic-Radovic, Dana

Uskokovic, Dragan

机构：

[1] Serbian Acad Arts & Sci, Inst Tech Sci, Belgrade, Serbia

[2] Univ Novi Sad, Fac Med, Clin Stomatol, Novi Sad, Serbia

[3] Univ Nis, Fac Med, Clin Stomatol, Nish, Serbia

[4] Inst Microelect Technol & Single Crystals, IHTM, Belgrade, Serbia

来源：

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY | 2007年 / 27卷 / 2-3期

关键词：

powders-chemical preparation; composites; interfaces; chemical properties; biomedical applications;

D O I：

10.1016/j.jeurceramsoc.2006.04.104

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 [材料科学与工程]; 080502 [材料学];

摘要：

A calcium phosphate/poly-D,L-lactide-co-glycolide (BCP/DLPLG) composite biomaterial was synthesized in the shape of spherical granules (150-200 mu m) and nanostructured particles (30-40 nm) by an emulsilication/evaporation procedure. Calcium phosphate components were coated with amorphous polymer phase. The influence of the processing technique on the structure and characteristics of the BCP/DLPLG composite biomaterial was studied by X-ray diffraction analysis (XRD), differential scanning calorimetry (DSC), scanning electronic microscopy (SEM), and atomic force microscopy (AFM). In vitro cytotoxicity research was conducted on cellular cultures of fibroblasts of animals. The possibility of BCP/DLPLG application was examined by its use in reparation of lost bone tissue of patients. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1589 / 1594

页数：6

共 28 条

[1]

Effect of blending calcium compounds on hydrolytic degradation of poly(DL-lactic acid-co-glycolic acid) [J].