Biological aspects of Epstein-Barr virus (EBV)-infected lymphocytes in chronic active EBV infection and associated malignancies

被引：44

作者：

Kanegane, H

Nomura, K

Miyawaki, T

Tosato, G

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Med, Dept Pediat, Sugitani, Toyama 9300194, Japan

[2] NCI, Expt Transplantat & Immunol Branch, Canc Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2002年 / 44卷 / 03期

关键词：

Epstein-Barr virus (EBV); malignancies; chronic active EBV infection; T-cell lymphoma;

D O I：

10.1016/S1040-8428(02)00115-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most primary Epstein-Barr virus (EBV) infections are clinically inapparent, but occasionally EBV-infection can cause acute infectious mononucleosis. EBV has been linked to a variety of hematologic and non-hematologic malignancies. Chronic active EBV (CAEBV) infection designates a recently identified EBV-associated syndrome characterized by a variety of serious hematological disorders, including malignant lymphoma. EBV was found to infect circulating T- and/or NK-cells in patients with CAEBV infection. These EBV-infected T- and/or NK-cells express EBNA-L LMP-1, and LMP-2A, a type II form of EBV latency, which is also observed in nasopharyngeal carcinoma (NPC), Hodgkin's disease (HD), and peripheral T-cell lymphoma. CAEBV infections may thus represent a subset of EBV-associated T- and/or NK-cell lymphoproliferative disorders. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：239 / 249

页数：11

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