Synthesis and hybridization properties of polyamide based nucleic acid analogues incorporating pyrrolidine-derived nucleoamino acids

被引：18

作者：

Altmann, KH

Hüsken, D

Cuenoud, B

García-Echeverría, C

机构：

[1] Novartis Pharma AG, TA Oncol Res, CH-4002 Basel, Switzerland

[2] Resp Dis TA, Horsham, W Sussex, England

[3] Funct Genom Area, Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)00121-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-delta-Fmoc protected nucleoamino acids of type I (Base = T, C, A) have been synthesized and employed as building blocks for the construction of novel polyamide based nucleic acid analogues, Homopyrimidine oligomer A binds to complementary RNA with significant affinity and in a sequence-specific fashion, while no binding was observed to complementary DNA. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：929 / 933

页数：5

共 34 条

[1] Polyamide based nucleic acid analogs - Synthesis of delta-amino acids with nucleic acid bases bearing side chains [J].