A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family

被引：21

作者：

Hamada, T ^{[1
]}

Ui-Tei, K ^{[1
]}

Miyata, Y ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Pharmacol, Bunkyo Ku, Tokyo 1138602, Japan

来源：

FEBS LETTERS | 2000年 / 475卷 / 02期

关键词：

spinal cord-derived growth factor; differential display; chick spinal cord; mitogenic activity; CUB domain; platelet-derived growth factor/vascular endothelial growth factor family;

D O I：

10.1016/S0014-5793(00)01640-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：97 / 102

页数：6

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