Antioxidant enzyme expression in health and disease: effects of exercise and hypertension

Antioxidant enzymes (superoxide dismutases, catalase and glutathione peroxidase) are components of an organism's mechanisms for combating oxidative stress which is generated in normal metabolism and which may also be a reaction in response to external stimuli. This review identifies the general significance of antioxidant enzymes in health and disease, and some of the diseases that are now believed to have oxidative stress as a component. A discussion is then presented of the molecular mechanisms by which antioxidant enzyme expression is controlled at the transcriptional and post-transcriptional levels. The final sections of the review highlight the effects of exercise and hypertension on antioxidant enzyme expression in a number of different tissues, and the possibilities for future studies in these areas are discussed. (C) 2002 Elsevier Science Inc. All rights reserved.