What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: An update

被引：174

作者：

Cheng, Zhiyong ^{[1
]}

Li, Yuanzong ^{[1
]}

机构：

[1] Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan & Mol Engn, Beijing 100871, Peoples R China

来源：

CHEMICAL REVIEWS | 2007年 / 107卷 / 03期

关键词：

LOW-DENSITY-LIPOPROTEIN; UNSATURATED FATTY-ACIDS; RAT-LIVER MICROSOMES; HYDROXYL RADICAL GENERATION; HUMAN SKIN FIBROBLASTS; INDUCED LDL OXIDATION; BOVINE SERUM-ALBUMIN; RED-BLOOD-CELLS; HYDROGEN-PEROXIDE; IN-VITRO;

D O I：

10.1021/cr040077w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An overview is given of proposed lipid peroxidation (LPO) initiators in the literature of the past few decades, focusing on the most effective species, namely, lipid peroxide (LOOH)-derived lipid radicals (secondary initiation), hypervalent iron complexes and enzymatic oxidation. The role of Fe(II), Fe(III), chelators and other metal cations in LPO initiation and inhibition is discussed, providing an overall picture of the initiating chemistry for LPO.

引用

页码：748 / 766

页数：19

共 312 条

[1] Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins [J].