Improving the efficacy of antibody-based cancer therapies

被引:639
作者
Carter, P [1 ]
机构
[1] Immunex Corp, Seattle, WA 98101 USA
关键词
D O I
10.1038/35101072
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A quarter of a century after their advent, monoclonal antibodies have become the most rapidly expanding class of pharmaceuticals for treating a wide variety of human diseases, including cancer. Although antibodies have yet to achieve the ultimate goal of curing cancer, many innovative approaches stand poised to improve the efficacy of antibody-based therapies.
引用
收藏
页码:118 / 129
页数:12
相关论文
共 140 条
  • [1] Adams GP, 2001, CANCER RES, V61, P4750
  • [2] Adams GP, 1998, CANCER RES, V58, P485
  • [3] ADAMS GP, 1993, CANCER RES, V53, P4026
  • [4] A potential role for activated HER-2 in prostate cancer
    Agus, DB
    Akita, RW
    Fox, WD
    Lofgren, JA
    Higgins, B
    Maiese, K
    Scher, HI
    Sliwkowski, MX
    [J]. SEMINARS IN ONCOLOGY, 2000, 27 (06) : 76 - 83
  • [5] Ajani JA, 2000, CANCER J, V6, P78
  • [6] BAKER TS, 1994, ANTIGEN ANTIBODY MOL
  • [7] Phase II study of weekly intravenous recombinant humanized Anti-p185(HER2) monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast
    Baselga, J
    Tripathy, D
    Mendelsohn, J
    Baughman, S
    Benz, CC
    Dantis, L
    Sklarin, NT
    Seidman, AD
    Hudis, CA
    Moore, J
    Rosen, PP
    Twaddell, T
    Henderson, IC
    Norton, L
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (03) : 737 - 744
  • [8] Baselga J, 1998, CANCER RES, V58, P2825
  • [9] Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library
    Begent, RHJ
    Verhaar, MJ
    Chester, KA
    Casey, JL
    Green, AJ
    Napier, MP
    HopeStone, LD
    Cushen, N
    Keep, PA
    Johnson, CJ
    Hawkins, RE
    Hilson, AJW
    Robson, L
    [J]. NATURE MEDICINE, 1996, 2 (09) : 979 - 984
  • [10] Immunoliposomes - A promising approach to targeting cancer therapy
    Bendas, G
    [J]. BIODRUGS, 2001, 15 (04) : 215 - 224