Candidate mechanisms for chemotherapy-induced cognitive changes

被引：689

作者：

Ahles, Tim A. ^{[1
]}

Saykin, Andrew J.

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, New York, NY 10021 USA

[2] Dartmouth Hitchcock Med Ctr, Dept Psychiat, Neuropsychol Program, Lebanon, NH 03766 USA

[3] Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Lebanon, NH 03766 USA

[4] New Hampshire Hosp, Concord, NH USA

[5] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46204 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 03期

关键词：

D O I：

10.1038/nrc2073

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanism(s) for chemotherapy-induced cognitive changes are largely unknown; however, several candidate mechanisms have been identified. We suggest that shared genetic risk factors for the development of cancer and cognitive problems, including low-efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune response, coupled with the effect of chemotherapy on these systems, might contribute to cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated reduction of capacity for neural repair and neurotransmitter activity, as well as reduced antioxidant capacity associated with treatment-induced reduction in oestrogen and testosterone levels, might interact with these mechanisms and/or have independent effects on cognitive function.

引用

页码：192 / 201

页数：10

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