XBP1: the last two decades

被引：101

作者：

Glimcher, L. H. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2010年 / 69卷

关键词：

UNFOLDED PROTEIN RESPONSE; PLASMA-CELL DIFFERENTIATION; TRANSCRIPTION FACTOR; ENDOPLASMIC-RETICULUM; BINDING-PROTEIN; CYCLIC-AMP; ER STRESS; KINASE; SUSCEPTIBILITY; ACTIVATION;

D O I：

10.1136/ard.2009.119388

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The transcription factor X box-binding protein 1 (XBP1) was isolated two decades ago in a search for regulators of major histocompatibility complex (MHC) class II gene expression. Many years of research finally revealed a protein with many functions, none of them related to the MHC. This paper provided an overview of what this multifunctional transcription factor actually does.

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收藏

页码：67 / 71

页数：5

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